Liam Payne consumed cocaine, alcohol, and a prescription antidepressant before falling to his death from a Buenos Aires hotel balcony last month, Argentine prosecutors said.

The prosecutor’s office added that three people were charged with supplying him with drugs and one of them was also charged with abandoning a person in a vulnerable state.

“The results of the toxicological studies, which have been communicated to his family, revealed that, in the moments prior to his death and over a period covering at least his last 72 hours, Payne had traces of polydrug use of alcohol, cocaine, and a prescription antidepressant in his body,” the prosecutors said.

Payne was found dead on Oct. 16 after plunging from the balcony of his third-floor room at the CasaSur Hotel in the Argentine capital.

An autopsy found he died after sustaining “multiple traumas” and “internal and external hemorrhaging” from the fall.

One of the highest-grossing live acts in the world in the 2010s, One Direction went on indefinite hiatus in 2016.

Payne went on to enjoy a degree of solo success but his career had languished recently.

His death at age 31 prompted a global outpouring of grief and condolences from family, former bandmates, fans and others.

Prosecutors said one of the three people charged in the case had accompanied him on a daily basis during his stay in Buenos Aires and was charged with abandoning a person who later died as well as supplying him with narcotics.

The second suspect is a hotel employee accused of twice supplying Payne with cocaine while he was staying at the CasaSur. A third person is also accused of supplying him with the drug on Oct. 14, two days before his death.

The prosecution ruled out self-harm and the “physical intervention of third parties” as the cause of Payne’s death, saying that the injuries he sustained were compatible with those caused by a fall.

“Payne was either not fully conscious or was in a state of markedly diminished or absent consciousness at the time of the fall,” the report said.

He was found dead after hotel staff called emergency services to report “a guest who is overwhelmed by drugs and alcohol, and destroying his room.”

Body flown home

The toxicological report was published a day after the singer’s father Geoff Payne repatriated his body to Britain aboard a flight from Buenos Aires to London.

Payne’s death has prompted a debate about whether the music industry has a duty of care for the mental health of stars who find fame at a young age.

The singer from Wolverhampton in central England had spoken publicly about struggles with substance abuse and the pressures of teenage stardom.

He first auditioned for the hugely popular television talent show The X Factor at the age of 14 but was unsuccessful.

Two years later he hit gold on the program, which teamed him up with Niall Horan, Harry Styles, Louis Tomlinson, and Zayn Malik to form One Direction.

Over the next six years, the group enjoyed global fame and legions of screaming fans, selling more than 70 million copies of their five albums. They went on four world tours and won nearly 200 awards.

Payne is survived by a seven-year-old boy, Bear, with Girls Aloud star Cheryl Tweedy. (AFP)